Fountain of Youth

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Going back for a second dessert after your holiday meal might not be the best strategy for living a long, cancer-free life say researchers from the University of Alabama at Birmingham. That's because they've shown exactly how restricted calorie diets -- specifically in the form of restricted glucose -- help human cells live longer.


This discovery, published online in The FASEB Journal, could help lead to drugs and treatments that slow human aging and prevent cancer.
"Our hope is that the discovery that reduced calories extends the lifespan of normal human cells will lead to further discoveries of the causes for these effects in different cell types and facilitate the development of novel approaches to extend the lifespan of humans," said Trygve Tollefsbol, Ph.D., a researcher involved in the work from the Center for Aging and Comprehensive Cancer Center at the University of Alabama at Birmingham. "We would also hope for these studies to lead to improved prevention of cancer as well as many other age-related diseases through controlling calorie intake of specific cell types."
To make this discovery, Tollefsbol and colleagues used normal human lung cells and precancerous human lung cells that were at the beginning stages of cancer formation. Both sets of cells were grown in the laboratory and received either normal or reduced levels of glucose (sugar). As the cells grew over a period of a few weeks, the researchers monitored their ability to divide, and kept track of how many cells survived over this period.

They found that the normal cells lived longer, and many of the precancerous cells died, when given less glucose. Gene activity was also measured under these same conditions. The reduced glucose caused normal cells to have a higher activity of the gene that dictates the level of telomerase, an enzyme that extends their lifespan and lower activity of a gene (p16) that slows their growth. Epigenetic effects (effects not due to gene mutations) were found to be a major cause in changing the activity of these genes as they reacted to decreased glucose levels.

"Western science is on the cusp of developing a pharmaceutical fountain of youth" said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study confirms that we are on the path to persuading human cells to let us to live longer, and perhaps cancer-free, lives."

[samurai69]

didnt read it but does it say anything about beer

[Cookie]

didnt read it but does it say anything about beer

No

[samurai69]

didnt read it but does it say anything about beer

No

GOOD

[Tuelfulhuden]

That post was really interesting, modern medicine is really reaching new heights, Imagine what they'll be able to do in 10 years.

[fits]

Interesting. I saw a programme before about this. A women ate fuck all every day, looked like a skellaton and she hopped to live to be over 100! what the fuck for when you live like that????


There is no doubt eating the wrong things and too much of anything will do you harm, make your body and organs over work, out put lots of insulin which is not good. But living like that??? whats the point in living.

.

[Cookie]

That post was really interesting, modern medicine is really reaching new heights, Imagine what they'll be able to do in 10 years.

It is nice that science is starting to recognise these things more & put the information out there for the general public. I remember watching a program in the mid 80`s about an American study (military I think) that had a guy on the bare minimum calories required for him to function each day, they took regular blood tests to track cellular damage, metabolic age & so on, end result, he was fitter & metabolically younger than those around him. The study was supposed to run for about 10-20 years but I have never come across anything else written about it.

Aubrey De Grey (Gray) is supposed to be a leading expert in the field of reduced calorie diets for those into life extension.

Interesting. I saw a programme before about this. A women ate fuck all every day, looked like a skellaton and she hopped to live to be over 100! what the fuck for when you live like that????


There is no doubt eating the wrong things and too much of anything will do you harm, make your body and organs over work, out put lots of insulin which is not good. But living like that??? whats the point in living.

I might have seen that one, remember reading that the body has the ability to live to 140 BUT it is programmed to self destruct & is not capable of living much beyond that, even my own GP says that we all have the potential to reach 100 in good shape is we are a little more frugal with food & excesses in our younger years.

[Al]

Cellular Autophagy

When the energy in the cell declines, the cell eats the damaged tissues for energy and that recycles the damaged tissues to make new material. The result is a healthier cell.

[Cookie]

Cellular Autophagy

When the energy in the cell declines, the cell eats the damaged tissues for energy and that recycles the damaged tissues to make new material. The result is a healthier cell.

Isn`t that what DeVany puts out in his Blueprint?

[Al]

Yes, one of the reasons he condones intermittent fasting

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